Immediate, long-lasting knee pain relief

iovera° is a non-surgical, FDA-approved treatment that blocks knee pain using extreme cold, providing immediate relief that lasts up to 90 days with just one treatment.

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What is iovera°?

iovera° is an FDA-approved non-opioid treatment that alleviates pain through a mechanism known as cryoanalgesia, which works by applying targeted extreme cold to nerves.

With the iovera° system, doctors are able to deliver precise, controlled doses of cold temperature only to the targeted nerve through a handheld device. This needle-based procedure is safe and does not damage or destroy the surrounding tissue.

Up to 90 days of relief with just one treatment

Immediate, long-lasting pain relief without drugs

No permanent damage

FDA-approved pain treatment

iovera FDA-approved non-opioid knee pain relief treatment using cryoanalgesia to target nerves with extreme cold

How does iovera° work?

The iovera° treatment blocks targeted sensory nerves from sending pain signals. A small probe (also referred to as Smart Tip) is inserted into the treatment region and a treatment cycle is performed.

A precise cold zone is formed under the skin—cold enough to temporarily stop the nerve from signaling without damaging surrounding tissue. This is repeated until the nerve is blocked, providing pain relief until the nerve regenerates.

The iovera° treatment is used to treat specific nerves so the pain relief is focused only on the part of the body that is being treated. One treatment with the iovera° system can last 90 days. [1]
How iovera works - an FDA-approved non-opioid knee pain relief treatment using cryoanalgesia to target nerves with extreme cold

Treatment results for chronic knee pain

Decreased knee pain

Patients who received iovera° treatment continued to experience pain relief at 90 days [1]

Less stiffness

Patients treated with the iovera° system experienced less stiffness 30 days after treatment [1]

Improved physical function

Patients in the iovera° treatment group had improved physical function at 90 days [1]

Treatment results for acute (post-surgical) knee pain

Fewer opioid perscriptions

Patients who received iovera° treatment requested 45% fewer opioid prescriptions at 12 weeks after knee replacement surgery [2]

Reduction in knee pain

2 weeks after surgery, patients treated with iovera° experienced less pain [2]

Faster discharge

More patients treated with iovera° were discharged within 2 days of surgery [2]

Free same-day phone consultation

Whether you're looking to learn more about iovera° treatment or want to get started at one of our facilities in Arizona, our team is here to help.

Call now or schedule a time for us to call you:

Free Same-Day Phone Consultations at Steward Orthopedic and Sports Medicine in Utah
Call (602) 780-0786

The iovera° system is used to destroy tissue during surgical procedures by applying freezing cold. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain. It is also indicated for the relief of pain and symptoms associated with osteoarthritis of the knee for up to 90 days. The iovera° system is not indicated for treatment of central nervous system tissue. The iovera° system’s “1x90” Smart Tip configuration (indicating one needle which is 90 mm long) can also facilitate target nerve location by conducting electrical nerve stimulation from a separate nerve stimulator.

Important Safety Information

The iovera° system should not be used in people with the following conditions:
Blood that thickens when patient is exposed to cold (cryoglobulinemia), blood appearing in the urine when patient is exposed to the cold (paroxysmal cold hemoglobinuria), skin rash that appears when patient is exposed to the cold (cold urticaria), narrowing of the blood vessels in the hands and feet when patient is exposed to the cold (Raynaud’s disease), and open and/or infected wounds at or near the treatment site

Patients being treated with the iovera° system (a needle-based therapy) may experience certain reactions, including, but not limited to:
Bruising, swelling, inflammation and/or redness, local pain and/or tenderness, and altered feeling at the site of application

Proper use of the device as described in the User Guide can help reduce or prevent the following reactions:
In the area(s) where you were treated: damage to the skin from being exposed to cold or heat, darkening or lightening of the skin, and dimples in the skin
Outside the area(s) where you were treated: muscles may not work or move normally


[1] Radnovich R, Scott D, Patel AT, et al. Cryoneurolysis to treat the pain and symptoms of knee osteoarthritis: a multicenter, randomized, double-blind, sham-controlled trial. Osteoarthritis Cartilage. 2017;25(8):1247-1256.
[2] Dasa V, Lensing G, Parsons M, Harris J, Volaufova J, Bliss R. Percutaneous freezing of sensory nerves prior to total knee arthroplasty. Knee. 2016;23(3):523-528.