Immediate, long-lasting knee pain relief
iovera° is a non-surgical, FDA-approved treatment that blocks knee pain using extreme cold, providing immediate relief that lasts up to 90 days with just one treatment.
Get started today with a free, same-day phone consultation with our concierge care team:
What is iovera°?
With the iovera° system, doctors are able to deliver precise, controlled doses of cold temperature only to the targeted nerve through a handheld device. This needle-based procedure is safe and does not damage or destroy the surrounding tissue.
Up to 90 days of relief with just one treatment
Immediate, long-lasting pain relief without drugs
No permanent damage
FDA-approved pain treatment
How does iovera° work?
A precise cold zone is formed under the skin—cold enough to temporarily stop the nerve from signaling without damaging surrounding tissue. This is repeated until the nerve is blocked, providing pain relief until the nerve regenerates.
The iovera° treatment is used to treat specific nerves so the pain relief is focused only on the part of the body that is being treated. One treatment with the iovera° system can last 90 days. 
Treatment results for chronic knee pain
Decreased knee pain
Patients who received iovera° treatment continued to experience pain relief at 90 days 
Patients treated with the iovera° system experienced less stiffness 30 days after treatment 
Improved physical function
Patients in the iovera° treatment group had improved physical function at 90 days 
Treatment results for acute (post-surgical) knee pain
Fewer opioid perscriptions
Patients who received iovera° treatment requested 45% fewer opioid prescriptions at 12 weeks after knee replacement surgery 
Reduction in knee pain
2 weeks after surgery, patients treated with iovera° experienced less pain 
More patients treated with iovera° were discharged within 2 days of surgery 
Free same-day phone consultation
Whether you're looking to learn more about iovera° treatment or want to get started at one of our facilities in Arizona, our team is here to help.
Call now or schedule a time for us to call you:
All Steward Orthopedic & Sports Medicine Locations in Arizona
Our Steward Hospitals
Mountain Vista Medical Center
Mesa, AZ 85209
Tempe St. Luke's Hospital
Tempe, AZ 85281
The iovera° system is used to destroy tissue during surgical procedures by applying freezing cold. It can also be used to produce lesions in peripheral nervous tissue by the application of cold to the selected site for the blocking of pain. It is also indicated for the relief of pain and symptoms associated with osteoarthritis of the knee for up to 90 days. The iovera° system is not indicated for treatment of central nervous system tissue. The iovera° system’s “1x90” Smart Tip configuration (indicating one needle which is 90 mm long) can also facilitate target nerve location by conducting electrical nerve stimulation from a separate nerve stimulator.
Important Safety Information
The iovera° system should not be used in people with the following conditions:
Blood that thickens when patient is exposed to cold (cryoglobulinemia), blood appearing in the urine when patient is exposed to the cold (paroxysmal cold hemoglobinuria), skin rash that appears when patient is exposed to the cold (cold urticaria), narrowing of the blood vessels in the hands and feet when patient is exposed to the cold (Raynaud’s disease), and open and/or infected wounds at or near the treatment site
Patients being treated with the iovera° system (a needle-based therapy) may experience certain reactions, including, but not limited to:
Bruising, swelling, inflammation and/or redness, local pain and/or tenderness, and altered feeling at the site of application
Proper use of the device as described in the User Guide can help reduce or prevent the following reactions:
In the area(s) where you were treated: damage to the skin from being exposed to cold or heat, darkening or lightening of the skin, and dimples in the skin
Outside the area(s) where you were treated: muscles may not work or move normally
 Radnovich R, Scott D, Patel AT, et al. Cryoneurolysis to treat the pain and symptoms of knee osteoarthritis: a multicenter, randomized, double-blind, sham-controlled trial. Osteoarthritis Cartilage. 2017;25(8):1247-1256.
 Dasa V, Lensing G, Parsons M, Harris J, Volaufova J, Bliss R. Percutaneous freezing of sensory nerves prior to total knee arthroplasty. Knee. 2016;23(3):523-528.